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pentobarbital will lower the extent or influence of carvedilol by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.pentobarbital will lower the extent or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could